XIAFLEX® is an FDA-approved, nonsurgical treatment for adults with Dupuytren’s contracture when a cord can be felt.
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Studies show that prescription XIAFLEX®, along with a finger extension procedure, may help straighten or nearly straighten the affected finger and improve range of motion after up to 3 injections.
XIAFLEX® is given:
- In a doctor’s office
- By a hand specialist with XIAFLEX® training
- With no general anesthesia required
Treatment with XIAFLEX® begins with finding a XIAFLEX®-trained hand specialist. Use our locator to find one in your area.
Find a hand specialist in your area
What Kind of Results Are Possible?
Individual results may vary. The following are real-world examples of treatment with XIAFLEX®:
This patient had a cord that could be felt causing a contracture of the MP (metacarpophalangeal) joint of the left ring finger. The cord was injected with XIAFLEX®, and a finger extension procedure was performed 48 hours later.
This patient had a cord that could be felt causing a contracture of the MP and PIP (proximal interphalangeal) joints of the left pinky finger. The cord was injected with XIAFLEX®, and a finger extension procedure was performed 48 hours later.
Patients had finger extensions performed by a physician; were fitted with a splint; and were instructed to use a splint at bedtime for up to 4 months and perform daily finger exercises.
In studies, patients received up to 3 injections of XIAFLEX® or placebo into a cord that could be felt at approximately 4-week intervals.
The most common side effects with XIAFLEX® for the treatment of Dupuytren’s contracture include swelling of the injection site or the hand; bruising or bleeding at the injection site; pain or tenderness of the injection site or the hand; swelling of the lymph nodes (glands) in the elbow or armpit; itching; breaks in the skin; redness or warmth of the skin; and pain in the armpit.
Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with XIAFLEX®. For more information, ask your healthcare provider or pharmacist.
Since 2010, it is estimated that more than 150,000 patients with Dupuytren’s contracture have been treated with XIAFLEX®.* Watch Ed’s story about his treatment experience.
*Through February 2020.
83% (206 out of 249) of patients were satisfied with XIAFLEX® compared with 30% (38 out of 125) of patients with placebo.*
*In 2 clinical studies, patients were asked to rate their satisfaction with treatment on Day 90 as “very satisfied,” “quite satisfied,” “neither satisfied nor dissatisfied,” “quite dissatisfied,” or “very dissatisfied.” For data analysis, “satisfied” includes patients who chose “very satisfied” or “quite satisfied.”
In these 2 clinical studies, patients received up to 3 injections of XIAFLEX® or placebo into a cord that could be felt on Days 0, 30, and 60. About 24 hours after each injection, patients had a finger extension procedure and were fitted with a splint to wear at bedtime for up to 4 months. Patients also performed finger exercises every day.
In these 2 studies, 60% of patients had a straight or nearly straight finger 30 days after the last injection on Days 30, 60, or 90 after up to 3 XIAFLEX® injections and finger extension procedures compared with 6% of patients who received placebo.
The most common side effects with XIAFLEX® in these studies were swelling of the injected hand and bruising or bleeding at the injection site.